منابع مشابه
Not too much and not too little.
The structure and function of any protein is determined by its amino acid sequence. Thus, the substitution of one amino acid for another can alter the activity of a protein or its function. Mutations—or rather, polymorphism, once they become fixed in the population—can be deleterious, such that the altered protein is no longer able to fulfil its role with potentially devastating effects on the ...
متن کاملTrace Minerals and Livestock: Not Too Much Not Too Little
The new approaches of the animal production systems make managing the mineral nutrition a challenge. Versus the excessive, trace mineral supply in intensively managed livestock, well above the physiological requirements, is the no trace mineral supplementation of organic systems, which become highly dependent on trace minerals in the soil. Nowadays, in addition to the animal health perspective,...
متن کاملLetter from . . . Denmark. Too much, not too little?
I Holmes, L. B., et al., Atlas of Mental Retardation. New York and London, 1972. 2 Caffey, J., Pediatrics, 1974, 54, 396. ' Mac Keith, R., Developmental Medicine and Child Neurology, 1974, 16, 216. 4 Smith, S. M., and Hanson, R., British Medical Journal, 1974, 3, 666. B Oliver, J. E., et al., Severely Ill-treated Young Children in North-east Wiltshire. Oxford University of Clinical Epidemiology...
متن کاملOral Iron Prophylaxis in Pregnancy: Not Too Little and Not Too Much!
An adequate supply of iron is essential for normal development of the fetus and newborn child. Iron deficiency and iron deficiency anemia (IDA) during pregnancy increase the risk of preterm birth and low birth weight. Iron is important for development of the fetal brain and cognitive abilities of the newborn. Children born to iron-deficient mothers will start their lives suffering from iron def...
متن کاملToo much or too little
The global effort to understand the molecular drivers of cancer onset and progression is now coming to fruition with the identification of specific genomic and epigenomic events that influence signaling through key oncogenic pathways. Genetic studies using inducible expression of the critical growth controlling oncogenes MYC, RAS, PI3K and AKT have shown unequivocally that, in conjunction with ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2012
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2012.153